A team of researchers at the Massachusetts Institute of Technology has uncovered a surprising biological mechanism that explains why humans lose focus and attention during the day after a night of insomnia or not getting enough sleep. The brain tries to “compensate” for the lack of natural cleansing processes that occur during deep sleep by releasing waves of cerebrospinal fluid (CSF) during wakefulness, but this comes at the cost of concentration, according to a study published in Nature Neuroscience. Study Details: Researchers conducted an experiment on 26 volunteers, with each participant taking two tests. The first time was after a night’s sleep, and the second time was after a night without sleep under laboratory supervision. The research team measured attention using advanced techniques such as high-speed fMRI, electroencephalography (EEG), pupillometry, and behavioral tests.
Research results
The results showed that after sleep deprivation, participants performed significantly worse on attention tasks, had significantly increased reaction times, and in some cases stopped noticing stimuli at all. Key finding: Moments of “loss of attention” or “mental fog” result in a pulsating flow of cerebrospinal fluid from the brain. This is the same process that normally occurs during deep sleep to remove waste products and toxins that have accumulated during the day. If the brain is deprived of this process during the night, it “secretly” starts this process during the day, but this comes at a “huge cost.”
temporarily lapsed in attention
Researchers’ statement: “When you don’t get these ‘fluid flow’ waves at night because you’ve been up all night, your brain secretly starts pumping them in during the day, but at the cost of attention,” said Laura Lewis, an associate professor in the Department of Electrical Engineering and Computer Science at Massachusetts Institute of Technology, who led the study.
She added: “Your brain is trying to catch up with the necessary cleansing process, even at the cost of concentration.”
Steps to understanding the effects of sleep deprivation
This study is an important step in understanding the neurological effects of sleep deprivation, explaining everyday phenomena such as ‘sudden forgetfulness’, slowed reaction times and the dangers of driving after a bad night. It also shows that these moments are not just “laziness” or “normal fatigue” but biological attempts to maintain long-term brain health.

